A small amount of fat does not affect piperaquine exposure in patients with malaria

• Main Authors: Anna Annerberg, Khin Maung Lwin, Niklas Lindegardh, Sakchai Khrutsawadchai, Elizabeth Ashley, Nicholas P.J. Day, Pratap Singhasivanon, Joel Tarning, Nicholas J. White, François Nosten
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/12361

Dihydroartemisinin-piperaquine is a new, highly effective, and well-Tolerated combination treatment for uncomplicated falciparum malaria. The lipophilic characteristic of piperaquine suggests that administration together with fat will increase the oral bioavailability of the drug, and this has been...