Pitfalls in estimating piperaquine elimination

By using a sensitive new assay, the terminal elimination half-life of the antimalarial piperaquine in a healthy volunteer was estimated to be 33 days, which is longer than estimated previously. This result illustrates the importance of extended sampling duration and sensitive assay methodologies in...

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Main Authors:	Joel Tarning, Niklas Lindegårdh, Anna Annerberg, Thida Singtoroj, Nicholas P.J. Day, Michael Ashton, Nicholas J. White
Other Authors:	Goteborg University, Sahlgrenska Academy
Format:	Article
Published:	2018
Subjects:	Medicine Pharmacology, Toxicology and Pharmaceutics
Online Access:	https://repository.li.mahidol.ac.th/handle/123456789/16719
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Institution:	Mahidol University

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record_format	dspace
spelling	th-mahidol.167192018-06-21T15:33:41Z Pitfalls in estimating piperaquine elimination Joel Tarning Niklas Lindegårdh Anna Annerberg Thida Singtoroj Nicholas P.J. Day Michael Ashton Nicholas J. White Goteborg University, Sahlgrenska Academy Mahidol University Medicine Pharmacology, Toxicology and Pharmaceutics By using a sensitive new assay, the terminal elimination half-life of the antimalarial piperaquine in a healthy volunteer was estimated to be 33 days, which is longer than estimated previously. This result illustrates the importance of extended sampling duration and sensitive assay methodologies in characterizing the disposition of slowly eliminated antimalarial drugs. Copyright © 2005, American Society for Microbiology. All Rights Reserved. 2018-06-21T08:20:11Z 2018-06-21T08:20:11Z 2005-12-01 Article Antimicrobial Agents and Chemotherapy. Vol.49, No.12 (2005), 5127-5128 10.1128/AAC.49.12.5127-5128.2005 00664804 2-s2.0-28844503112 https://repository.li.mahidol.ac.th/handle/123456789/16719 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=28844503112&origin=inward
institution	Mahidol University
building	Mahidol University Library
continent	Asia
country	Thailand Thailand
content_provider	Mahidol University Library
collection	Mahidol University Institutional Repository
topic	Medicine Pharmacology, Toxicology and Pharmaceutics
spellingShingle	Medicine Pharmacology, Toxicology and Pharmaceutics Joel Tarning Niklas Lindegårdh Anna Annerberg Thida Singtoroj Nicholas P.J. Day Michael Ashton Nicholas J. White Pitfalls in estimating piperaquine elimination
description	By using a sensitive new assay, the terminal elimination half-life of the antimalarial piperaquine in a healthy volunteer was estimated to be 33 days, which is longer than estimated previously. This result illustrates the importance of extended sampling duration and sensitive assay methodologies in characterizing the disposition of slowly eliminated antimalarial drugs. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
author2	Goteborg University, Sahlgrenska Academy
author_facet	Goteborg University, Sahlgrenska Academy Joel Tarning Niklas Lindegårdh Anna Annerberg Thida Singtoroj Nicholas P.J. Day Michael Ashton Nicholas J. White
format	Article
author	Joel Tarning Niklas Lindegårdh Anna Annerberg Thida Singtoroj Nicholas P.J. Day Michael Ashton Nicholas J. White
author_sort	Joel Tarning
title	Pitfalls in estimating piperaquine elimination
title_short	Pitfalls in estimating piperaquine elimination
title_full	Pitfalls in estimating piperaquine elimination
title_fullStr	Pitfalls in estimating piperaquine elimination
title_full_unstemmed	Pitfalls in estimating piperaquine elimination
title_sort	pitfalls in estimating piperaquine elimination
publishDate	2018
url	https://repository.li.mahidol.ac.th/handle/123456789/16719
_version_	1763488559266791424

Pitfalls in estimating piperaquine elimination

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