C-reactive protein induces high-mobility group box-1 protein release through activation of p38MAPK in macrophage RAW264.7 cells

• Main Authors: Ko ichi Kawahara, Kamal Krishna Biswas, Masako Unoshima, Takashi Ito, Kiyoshi Kikuchi, Yoko Morimoto, Masahiro Iwata, Salunya Tancharoen, Yoko Oyama, Kazunori Takenouchi, Yuko Nawa, Noboru Arimura, Meng Xiao Jie, Binita Shrestha, Naoki Miura, Toshiaki Shimizu, Kentaro Mera, Shin ichiro Arimura, Noboru Taniguchi, Hideo Iwasaka, Sonshin Takao, Teruto Hashiguchi, Ikuro Maruyama
• Other Authors: Kagoshima University
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/19684
• Institution: Mahidol University

Background: C-reactive protein (CRP) is widely used as a sensitive biomarker for inflammation. Increasing evidence suggests that CRP plays a role in inflammation. High-mobility group box-1 (HMGB1), a primarily nuclear protein, is passively released into the extracellular milieu by necrotic or damage...