1,5-Anhydro-d-fructose attenuates lipopolysaccharide-induced cytokine release via suppression of NF-κB p65 phosphorylation

by Xiaojie Meng, Ko ichi Kawahara, Yuko Nawa, Naoki Miura, Binita Shrestha, Salunya Tancharoen, Hisayo Sameshima, Teruto Hashiguchi, Ikuro Maruyama
Published 2018

Potential of the angiotensin receptor blockers (ARBs) telmisartan, irbesartan, and candesartan for inhibiting the HMGB1/RAGE axis in prevention and acute treatment of stroke

by Kiyoshi Kikuchi, Salunya Tancharoen, Takashi Ito, Yoko Morimoto-Yamashita, Naoki Miura, Ko ichi Kawahara, Ikuro Maruyama, Yoshinaka Murai, Eiichiro Tanaka
Published 2018

Green tea extract supplement inhibition of HMGB1 release in rats exposed to cigarette smoke

by Tawee Saiwichai, Vanida Sangalangkarn, Ko Ichi Kawahara, Yoko Oyama, Sirintip Chaichalotornkul, Somphong Narkpinit, Pongchai Harnyuttanakorn, Pratap Singhasivanon, Ikuro Maruyama, Salunya Tancharoen
Published 2018

Nucleophosmin may act as an alarmin: Implications for severe sepsis

by Yuko Nawa, Ko Ichi Kawahara, Salunya Tancharoen, Xiaojie Meng, Hisayo Sameshima, Takashi Ito, Yoshiki Masuda, Hitoshi Imaizumi, Teruto Hashiguchi, Ikuro Maruyama
Published 2018

High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy

by Yoko Oyama, Teruto Hashiguchi, Noboru Taniguchi, Salunya Tancharoen, Tomonori Uchimura, Kamal K. Biswas, Ko Ichi Kawahara, Takao Nitanda, Yoshihisa Umekita, Martin Lotz, Ikuro Maruyama
Published 2018

Thrombomodulin exerts cytoprotective effect on low-dose UVB-irradiated HaCaT cells

by Masahiro Iwata, Ko ichi Kawahara, Hisashi Kawabata, Takashi Ito, Kentaro Mera, Kamal Krishna Biswas, Salunya Tancharoen, Yuko Higashi, Kiyoshi Kikuchi, Teruto Hashiguchi, Takuro Kanekura, Ikuro Maruyama
Published 2018

Cleavage of host cytokeratin-6 by lysine-specificgingipain induces gingival inflammation in periodontitis patients

by Salunya Tancharoen, Takashi Matsuyama, Ko Ichi Kawahara, Kenji Tanaka, Lyang Ja Lee, Miho Machigashira, Kazuyuki Noguchi, Takashi Ito, Takahisa Imamura, Jan Potempa, Kiyoshi Kikuchi, Ikuro Maruyama
Published 2018

Involvement of the endocannabinoid system in periodontal healing

by Sayaka Kozono, Takashi Matsuyama, Kamal Krishna Biwasa, Ko ichi Kawahara, Yumiko Nakajima, Takehiko Yoshimoto, Yutaka Yonamine, Hideshi Kadomatsu, Salunya Tancharoen, Teruto Hashiguchi, Kazuyuki Noguchi, Ikuro Maruyama
Published 2018

HMGB1 as a therapeutic target in spinal cord injury: A hypothesis for novel therapy development (Review)

by Kiyoshi Kikuchi, Hisaaki Uchikado, Naoki Miura, Yoko Morimoto, Takashi Ito, Salunya Tancharoen, Kei Miyata, Rokudai Sakamoto, Chiemi Kikuchi, Narumi Iida, Naoto Shiomi, Terukazu Kuramoto, Naohisa Miyagi, Ko Ichi Kawahara
Published 2018

Induction of high mobility group box 1 release from serotonin-stimulated human umbilical vein endothelial cells

by Ko Ichi Kawahara, Teruto Hashiguchi, Kiyoshi Kikuchi, Salunya Tancharoen, Naoki Miura, Takashi Ito, Yoko Oyama, Yuko Nawa, Kamal K. Biswas, Xiaojie Meng, Yoko Morimoto, Binita Shrestha, Hisayo Sameshima, Ikuro Maruyama
Published 2018

Inhibition of HMGB1 by deep ocean water attenuates endotoxin-induced sepsis

by Ko ichi Kawahara, Teruto Hashiguchi, Takashi Ito, Kiyoshi Kikuchi, Yoko Morimoto, Toshiaki Shimizu, Yoko Oyama, Kazunori Takenouchi, Shin ichiro Arimura, Noboru Taniguchi, Ikuro Maruyama, Masahiro Iwata, Salunya Tancharoen, Masako Unoshima, Hideo Iwasaka
Published 2018

Application of a novel anti-adhesive membrane, E8002, in a rat laminectomy model

by Kiyoshi Kikuchi, Kentaro Setoyama, Takuto Terashi, Megumi Sumizono, Salunya Tancharoen, Shotaro Otsuka, Seiya Takada, Kazuki Nakanishi, Koki Ueda, Harutoshi Sakakima, Ko Ichi Kawahara, Ikuro Maruyama, Gohsuke Hattori, Motohiro Morioka, Eiichiro Tanaka, Hisaaki Uchikado
Published 2019

Beyond free radical scavenging: Beneficial effects of edaravone (Radicut) in various diseases (Review)

by Kiyoshi Kikuchi, Nobuyuki Takeshige, Naoki Miura, Yoko Morimoto, Takashi Ito, Salunya Tancharoen, Kei Miyata, Chiemi Kikuchi, Narumi Iida, Hisaaki Uchikado, Naohisa Miyagi, Naoto Shiomi, Terukazu Kuramoto, Ikuro Maruyama, Motohiro Morioka, Ko Ichi Kawahara
Published 2018

Tlr4/md-2 is a receptor for extracellular nucleophosmin 1

by Kota Nakatomi, Hikari Ueno, Yuto Ishikawa, Ronny Christiadi Salim, Yuki Mori, Issey Kanemoto, Salunya Tancharoen, Kiyoshi Kikuchi, Naoki Miura, Taketo Omori, Emiko Okuda-Ashitaka, Kiyoshi Matsumura, Hitoshi Imaizumi, Yoshihiro Motomiya, Ikuro Maruyama, Ko Ichi Kawahara
Published 2021

Secondary prevention of stroke: Pleiotropic effects of optimal oral pharmacotherapy (review)

by Kiyoshi Kikuchi, Ko Ichi Kawahara, Naoki Miura, Takashi Ito, Yoko Morimoto, Salunya Tancharoen, Nobuyuki Takeshige, Hisaaki Uchikado, Rokudai Sakamoto, Naohisa Miyagi, Chiemi Kikuchi, Narumi Iida, Naoto Shiomi, Terukazu Kuramoto, Masaru Hirohata, Ikuro Maruyama, Motohiro Morioka, Eiichiro Tanaka
Published 2018

E8002 inhibits peripheral nerve adhesion by enhancing fibrinolysis of l-ascorbic acid in a rat sciatic nerve model

by Kiyoshi Kikuchi, Kentaro Setoyama, Seiya Takada, Shotaro Otsuka, Kazuki Nakanishi, Kosuke Norimatsu, Akira Tani, Harutoshi Sakakima, Ko Ichi Kawahara, Kazuya Hosokawa, Ryoji Kiyama, Megumi Sumizono, Salunya Tancharoen, Ikuro Maruyama, Gohsuke Hattori, Motohiro Morioka, Eiichiro Tanaka, Hisaaki Uchikado
Published 2020

Uric acid enhances alteplase-mediated thrombolysis as an antioxidant

by Kiyoshi Kikuchi, Kentaro Setoyama, Eiichiro Tanaka, Shotaro Otsuka, Takuto Terashi, Kazuki Nakanishi, Seiya Takada, Harutoshi Sakakima, Sumate Ampawong, Ko ichi Kawahara, Tomoka Nagasato, Kazuya Hosokawa, Yoichiro Harada, Mika Yamamoto, Chinatsu Kamikokuryo, Ryoji Kiyama, Motohiro Morioka, Takashi Ito, Ikuro Maruyama, Salunya Tancharoen
Published 2019

Mechanism of HMGB1 release inhibition from RAW264.7 cells by oleanolic acid in Prunus mume Sieb. et Zucc

by Ko Ichi Kawahara, Teruto Hashiguchi, Kazuo Masuda, Abbi R. Saniabadi, Kiyoshi Kikuchi, Salunya Tancharoen, Takashi Ito, Naoki Miura, Yoko Morimoto, Kamal K. Biswas, Yuko Nawa, Xiaojie Meng, Yoko Oyama, Kazunori Takenouchi, Binita Shrestha, Hisayo Sameshima, Toshiaki Shimizu, Taro Adachi, Masakazu Adachi, Ikuro Maruyama
Published 2018

The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells

by Kiyoshi Kikuchi, Ko Ichi Kawahara, Salunya Tancharoen, Fumiyo Matsuda, Yoko Morimoto, Takashi Ito, Kamal Krishna Biswas, Kazunori Takenouchi, Naoki Miura, Yoko Oyama, Yuko Nawa, Noboru Arimura, Masahiro Iwata, Yutaka Tajima, Terukazu Kuramoto, Kenji Nakayama, Minoru Shigemori, Yoshihiro Yoshida, Teruto Hashiguchi, Ikuro Maruyama
Published 2018

Edaravone: A new therapeutic approach for the treatment of acute stroke

by Kiyoshi Kikuchi, Ko Ichi Kawahara, Naohisa Miyagi, Hisaaki Uchikado, Terukazu Kuramoto, Yoko Morimoto, Salunya Tancharoen, Naoki Miura, Kazunori Takenouchi, Yoko Oyama, Binita Shrestha, Fumiyo Matsuda, Yoshihiro Yoshida, Shinichiro Arimura, Kentaro Mera, Ko Ichi Tada, Narimasa Yoshinaga, Ryuichi Maenosono, Yoshiko Ohno, Teruto Hashiguchi, Ikuro Maruyama, Minoru Shigemori
Published 2018