Genome-wide and fine-resolution association analysis of malaria in West Africa

• Main Authors: Muminatou Jallow, Yik Ying Teo, Kerrin S. Small, Kirk A. Rockett, Panos Deloukas, Taane G. Clark, Katja Kivinen, Kalifa A. Bojang, David J. Conway, Margaret Pinder, Giorgio Sirugo, Fatou Sisay-Joof, Stanley Usen, Sarah Auburn, Suzannah J. Bumpstead, Susana Campino, Alison Coffey, Andrew Dunham, Andrew E. Fry, Angela Green, Rhian Gwilliam, Sarah E. Hunt, Michael Inouye, Anna E. Jeffreys, Alieu Mendy, Aarno Palotie, Simon Potter, Jiannis Ragoussis, Jane Rogers, Kate Rowlands, Elilan Somaskantharajah, Pamela Whittaker, Claire Widden, Peter Donnelly, Bryan Howie, Jonathan Marchini, Andrew Morris, Miguel Sanjoaquin, Eric Akum Achidi, Tsiri Agbenyega, Angela Allen, Olukemi Amodu, Patrick Corran, Abdoulaye Djimde, Amagana Dolo, Ogobara K. Doumbo, Chris Drakeley, Sarah Dunstan, Jennifer Evans, Jeremy Farrar, Deepika Fernando, Tran Tinh Hien, Rolf D. Horstmann, Muntaser Ibrahim, Nadira Karunaweera, Gilbert Kokwaro, Kwadwo A. Koram, Martha Lemnge, Julie Makani, Kevin Marsh, Pascal Michon, David Modiano, Malcolm E. Molyneux, Ivo Mueller, Michael Parker, Norbert Peshu, Christopher V. Plowe, Odile Puijalon, John Reeder, Hugh Reyburn, Eleanor M. Riley, Anavaj Sakuntabhai, Pratap Singhasivanon, Sodiomon Sirima, Adama Tall, Terrie E. Taylor, Mahamadou Thera, Marita Troye-Blomberg, Thomas N. Williams, Michael Wilson, Dominic P. Kwiatkowski
• Other Authors: Medical Research Council Laboratories Gambia
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/27218
• Institution: Mahidol University

We report a genome-wide association (GWA) study of severe malaria in The Gambia. The initial GWA scan included 2,500 children genotyped on the Affymetrix 500K GeneChip, and a replication study included 3,400 children. We used this to examine the performance of GWA methods in Africa. We found conside...