Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): An open-label, randomised trial

• Main Authors: Arjen M. Dondorp, Caterina I. Fanello, Ilse Ce Hendriksen, Ermelinda Gomes, Amir Seni, Kajal D. Chhaganlal, Kalifa Bojang, Rasaq Olaosebikan, Nkechinyere Anunobi, Kathryn Maitland, Esther Kivaya, Tsiri Agbenyega, Samuel Blay Nguah, Jennifer Evans, Samwel Gesase, Catherine Kahabuka, George Mtove, Behzad Nadjm, Jacqueline Deen, Juliet Mwanga-Amumpaire, Margaret Nansumba, Corine Karema, Noella Umulisa, Aline Uwimana, Olugbenga A. Mokuolu, Olanrewaju T. Adedoyin, Wahab Br Johnson, Antoinette K. Tshefu, Marie A. Onyamboko, Tharisara Sakulthaew, Wirichada Pan Ngum, Kamolrat Silamut, Kasia Stepniewska, Charles J. Woodrow, Delia Bethell, Bridget Wills, Martina Oneko, Tim E. Peto, Lorenz Von Seidlein, Nicholas Pj Day, Nicholas J. White
• Other Authors: Hospital Central da Beira
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/29443
• Institution: Mahidol University

Severe malaria is a major cause of childhood death and often the main reason for paediatric hospital admission in sub-Saharan Africa. Quinine is still the established treatment of choice, although evidence from Asia suggests that artesunate is associated with a lower mortality. We compared parentera...