Mitochondrial complex i deficiency increases protein acetylation and accelerates heart failure

Mitochondrial respiratory dysfunction is linked to the pathogenesis of multiple diseases, including heart failure, but the specific mechanisms for this link remain largely elusive. We modeled the impairment of mitochondrial respiration by the inactivation of the Ndufs4 gene, a protein critical for c...

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Bibliographic Details
Main Authors: Georgios Karamanlidis, Chi Fung Lee, Lorena Garcia-Menendez, Stephen C. Kolwicz, Wichit Suthammarak, Guohua Gong, Margaret M. Sedensky, Philip G. Morgan, Wang Wang, Rong Tian
Other Authors: University of Washington, Seattle
Format: Article
Published: 2018
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/31245
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Institution: Mahidol University

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