Mechanisms of inhibition of Rhizobium etli pyruvate carboxylase by L-Aspartate

• Main Authors: Chaiyos Sirithanakorn, Abdussalam Adina-Zada, John C. Wallace, Sarawut Jitrapakdee, Paul V. Attwood
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/33207

© 2014 American Chemical Society. L-Aspartate is a regulatory feedback inhibitor of the biotin-dependent enzyme pyruvate carboxylase in response to increased levels of tricarboxylic acid cycle intermediates. Detailed studies of L-aspartate inhibition of pyruvate carboxylase have been mainly confined...