Mutation screening and association study of the folylpolyglutamate synthetase (FPGS) gene with susceptibility to childhood acute lymphoblastic leukemia

Mutation screening and association study of the folylpolyglutamate synthetase (FPGS) gene with susceptibility to childhood acute lymphoblastic leukemia

Background: Folylpolyglutamate synthetase (FPGS), an important enzyme in the folate metabolic pathway, plays a central role in intracellular accumulation of folate and antifolate in several mammalian cell types. Loss of FPGS activity results in decreased cellular levels of antifolates and consequent...

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Main Authors: Duangjai Piwkham, Teerapong Siriboonpiputtana, Joke Beuten, Samart Pakakasama, Jonathan A.L. Gelfond, Karan Paisooksantivatana, Gail E. Tomlinson, Budsaba Rerkamnuaychoke
Other Authors: Mahidol University
Format: Article
Published: 2018
Subjects:
Biochemistry, Genetics and Molecular Biology
Medicine
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/35589
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Institution: Mahidol University

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https://repository.li.mahidol.ac.th/handle/123456789/35589

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