Mutation screening and association study of the folylpolyglutamate synthetase (FPGS) gene with susceptibility to childhood acute lymphoblastic leukemia

• Main Authors: Duangjai Piwkham, Teerapong Siriboonpiputtana, Joke Beuten, Samart Pakakasama, Jonathan A.L. Gelfond, Karan Paisooksantivatana, Gail E. Tomlinson, Budsaba Rerkamnuaychoke
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/35589

Background: Folylpolyglutamate synthetase (FPGS), an important enzyme in the folate metabolic pathway, plays a central role in intracellular accumulation of folate and antifolate in several mammalian cell types. Loss of FPGS activity results in decreased cellular levels of antifolates and consequent...