MAIT cells are activated during human viral infections

• Main Authors: Bonnie Van Wilgenburg, Iris Scherwitzl, Edward C. Hutchinson, Tianqi Leng, Ayako Kurioka, Corinna Kulicke, Catherine De Lara, Suzanne Cole, Sirijitt Vasanawathana, Wannee Limpitikul, Prida Malasit, Duncan Young, Laura Denney, Michael D. Moore, Paolo Fabris, Maria Teresa Giordani, Ye Htun Oo, Stephen M. Laidlaw, Lynn B. Dustin, Ling Pei Ho, Fiona M. Thompson, Narayan Ramamurthy, Juthathip Mongkolsapaya, Christian B. Willberg, Gavin R. Screaton, Paul Klenerman, Eleanor Barnes, Jonathan Ball, Gary Burgess, Graham Cooke, John Dillon, Charles Gore, Graham Foster, Neil Guha, Rachel Halford, Cham Herath, Chris Holmes, Anita Howe, Emma Hudson, William Irving, Salim Khakoo, Diana Koletzki, Natasha Martin, Tamyo Mbisa, Jane McKeating, John McLauchlan, Alec Miners, Andrea Murray, Peter Shaw, Peter Simmonds, Chris Spencer, Paul Targett-Adams, Emma Thomson, Peter Vickerman, Nicole Zitzmann
• Other Authors: Nuffield Department of Clinical Medicine
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/42998
• Institution: Mahidol University

Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize bacterial ligands. Here, we demonstrate that MAIT cells are also activated during human viral infections in vivo. MAIT cells activation was observed during infection with dengue virus, hepatitis C virus and influenza vi...