Artemether-lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania.

Artemether-lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania.

Artemether-lumefantrine is currently first-line therapy of Plasmodium falciparum malaria in many countries. This report describes a treatment failure despite adequate drug concentrations in a traveller returning from sub-Saharan Africa. Genotyping confirmed recrudescence and suggested reduced se...

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Bibliographic Details
Main Authors: Färnert, Anna, Ursing, Johan, Tolfvenstam, Thomas, Rono, Josea, Karlsson, Lillemor, Sparrelid, Elda, Lindegårdh, Niklas
Other Authors: anna.farnert@ki.se
Language:English
Published: 2014
Subjects:
Artemisnin
Lumefantrine
Malaria
non-immune
P. falciparum
Open Access article
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/666
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Institution: Mahidol University
Language: English
Description
Summary:Artemether-lumefantrine is currently first-line therapy of Plasmodium falciparum malaria in many countries. This report describes a treatment failure despite adequate drug concentrations in a traveller returning from sub-Saharan Africa. Genotyping confirmed recrudescence and suggested reduced sensitivity. Potential sub-optimal effect of artemether-lumefantrine highlights the need to follow non-immune individuals the weeks after treatment.

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