Mechanistic Modeling of Primaquine Pharmacokinetics, Gametocytocidal Activity, and Mosquito Infectivity

Mechanistic Modeling of Primaquine Pharmacokinetics, Gametocytocidal Activity, and Mosquito Infectivity

Clinical studies have shown that adding a single 0.25 mg base/kg dose of primaquine to standard antimalarial regimens rapidly sterilizes Plasmodium falciparum gametocytes. However, the mechanism of action and overall impact on malaria transmission is still unknown. Using data from 81 adult Malians w...

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Bibliographic Details
Main Authors: Palang Chotsiri, Almahamoudou Mahamar, Richard M. Hoglund, Fanta Koita, Koualy Sanogo, Halimatou Diawara, Alassane Dicko, Julie A. Simpson, Teun Bousema, Nicholas J. White, Joelle M. Brown, Roly Gosling, Ingrid Chen, Joel Tarning
Other Authors: Faculty of Tropical Medicine, Mahidol University
Format: Article
Published: 2022
Subjects:
Medicine
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/74762
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Institution: Mahidol University

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https://repository.li.mahidol.ac.th/handle/123456789/74762

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