Mechanistic Modeling of Primaquine Pharmacokinetics, Gametocytocidal Activity, and Mosquito Infectivity
Clinical studies have shown that adding a single 0.25 mg base/kg dose of primaquine to standard antimalarial regimens rapidly sterilizes Plasmodium falciparum gametocytes. However, the mechanism of action and overall impact on malaria transmission is still unknown. Using data from 81 adult Malians w...
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Main Authors: | , , , , , , , , , , , , , |
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Format: | Article |
Published: |
2022
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Subjects: | |
Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/74762 |
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Institution: | Mahidol University |