Mechanistic Modeling of Primaquine Pharmacokinetics, Gametocytocidal Activity, and Mosquito Infectivity
Clinical studies have shown that adding a single 0.25 mg base/kg dose of primaquine to standard antimalarial regimens rapidly sterilizes Plasmodium falciparum gametocytes. However, the mechanism of action and overall impact on malaria transmission is still unknown. Using data from 81 adult Malians w...
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Main Authors: | Palang Chotsiri, Almahamoudou Mahamar, Richard M. Hoglund, Fanta Koita, Koualy Sanogo, Halimatou Diawara, Alassane Dicko, Julie A. Simpson, Teun Bousema, Nicholas J. White, Joelle M. Brown, Roly Gosling, Ingrid Chen, Joel Tarning |
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Other Authors: | Faculty of Tropical Medicine, Mahidol University |
Format: | Article |
Published: |
2022
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Subjects: | |
Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/74762 |
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Institution: | Mahidol University |
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