Clinical Study of Single-Stranded Oligonucleotide RO7062931 in Healthy Volunteers and Patients With Chronic Hepatitis B

• Main Authors: Edward Gane, Man Fung Yuen, Dong Joon Kim, Henry Lik Yuen Chan, Bernadette Surujbally, Vedran Pavlovic, Sudip Das, Miriam Triyatni, Remi Kazma, Joseph F. Grippo, Simon Buatois, Annabelle Lemenuel-Diot, Ben Fillippo Krippendorff, Henrik Mueller, Yuchen Zhang, Hyung Joon Kim, Apinya Leerapun, Tien Huey Lim, Young Suk Lim, Tawesak Tanwandee, Won Kim, Wendy Cheng, Tsung Hui Hu, Cynthia Wat
• 其他作者: Siriraj Hospital
• 格式: Article
• 出版: 2022
• 主題: Medicine
• 在線閱讀: https://repository.li.mahidol.ac.th/handle/123456789/77820
• 機構: Mahidol University

Background and Aims: RO7062931 is an N-acetylgalactosamine (GalNAc)-conjugated single-stranded locked nucleic acid oligonucleotide complementary to HBV RNA. GalNAc conjugation targets the liver through the asialoglycoprotein receptor (ASGPR). This two-part phase 1 study evaluated the safety, pharmac...