Clinical Study of Single-Stranded Oligonucleotide RO7062931 in Healthy Volunteers and Patients With Chronic Hepatitis B

Clinical Study of Single-Stranded Oligonucleotide RO7062931 in Healthy Volunteers and Patients With Chronic Hepatitis B

Background and Aims: RO7062931 is an N-acetylgalactosamine (GalNAc)-conjugated single-stranded locked nucleic acid oligonucleotide complementary to HBV RNA. GalNAc conjugation targets the liver through the asialoglycoprotein receptor (ASGPR). This two-part phase 1 study evaluated the safety, pharmac...

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Main Authors: Edward Gane, Man Fung Yuen, Dong Joon Kim, Henry Lik Yuen Chan, Bernadette Surujbally, Vedran Pavlovic, Sudip Das, Miriam Triyatni, Remi Kazma, Joseph F. Grippo, Simon Buatois, Annabelle Lemenuel-Diot, Ben Fillippo Krippendorff, Henrik Mueller, Yuchen Zhang, Hyung Joon Kim, Apinya Leerapun, Tien Huey Lim, Young Suk Lim, Tawesak Tanwandee, Won Kim, Wendy Cheng, Tsung Hui Hu, Cynthia Wat
Other Authors: Siriraj Hospital
Format: Article
Published: 2022
Subjects:
Medicine
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/77820
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Institution: Mahidol University

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