Glucose-6-phosphate dehydrogenase activity in individuals with and without malaria: Analysis of clinical trial, cross-sectional and case–control data from Bangladesh

• Main Authors: Benedikt Ley, Mohammad Shafiul Alam, Mohammad Golam Kibria, Jutta Marfurt, Ching Swe Phru, Jenifar Quaiyum Ami, Kamala Thriemer, Sarah Auburn, Nusrat Jahan, Fatema Tuj Johora, Mohammad Sharif Hossain, Cristian Koepfli, Wasif Ali Khan, Ric N. Price
• Other Authors: Faculty of Tropical Medicine, Mahidol University
• Format: Article
• Published: 2022
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/78290
• Institution: Mahidol University

Background Glucose-6-phosphate dehydrogenase (G6PD) activity is dependent upon G6PD genotype and age of the red blood cell (RBC) population, with younger RBCs having higher activity. Peripheral parasitemia with Plasmodium spp. induces hemolysis, replacing older RBCs with younger cells with higher G6...