OVERRIDING CISPLATIN RESISTANCE IN LUNG SQUAMOUS CELL CARCINOMA: INSIGHTS FROM COMBINATION WITH HDAC INHIBITOR

by KONG LI REN
Published 2014

Sustained IKK beta phosphorylation and NF-kappa B activation by superoxide-induced peroxynitrite-mediated nitrotyrosine modification of B56 gamma 3 and PP2A inactivation

by Yee, Yi Hui, Chong, Stephen Jun Fei, Kong, Li Ren, Goh, Boon Cher, Pervaiz, Shazib
Published 2022

Characterization of MET-N375S as an Activating Mutation in Squamous Cell Carcinoma of the Lung

by Kong, Li Ren, Salleh, Nur Afiqah Binte Mohamed, Tan, Tuan Zea, Kappei, Dennis, Gohz, Boon Cher
Published 2024

Metabolic reprogramming of oncogene-addicted cancer cells to OXPHOS as a mechanism of drug resistance

by Hirpara, Jayshree, Eu, Jie Qing, Tan, Joanna Kia Min, Wong, Andrea L., Clement, Marie-Veronique, Kong, Li Ren, Ohi, Naoto, Tsunoda, Takeshi, Qu, Jianhua, Goh, Boon Cher, Pervaiz, Shazib
Published 2020

MEK Inhibition Overcomes Cisplatin Resistance Conferred by SOS/MAPK Pathway Activation in Squamous Cell Carcinoma

by Kong, Li Ren, Chua, Kian Ngiap, Sim, Wen Jing, Ng, Hsien Chun, Bi, Chonglei, Ho, Jingshan, Nga, Min En, Pang, Yin Huei, Ong, Weijie Richard, Soo, Ross Andrew, Huynh, The Hung, Chng, Wee Joo, Thiery, Jean-Paul, Goh, Boon Cher
Published 2020

A novel combinatorial strategy using Seliciclib (R) and Belinostat (R) for eradication of non-small cell lung cancer via apoptosis induction and BID activation

by Ong, Pei-Shi, Wang, Lingzhi, Chia, Deborah Miao-Hui, Seah, Jolyn Yu-Xin, Kong, Li-Ren, Thuya, Win-Lwin, Chinnathambi, Arunachalam, Lau, Jie-Ying Amelia, Wong, Andrea Li-Ann, Yong, Wei-Peng, Yang, Daiwen, Ho, Paul Chi-Lui, Sethi, Gautam, Goh, Boon-Cher
Published 2020

Pan-HDAC inhibition by panobinostat mediates chemosensitization to carboplatin in non-small cell lung cancer via attenuation of EGFR signaling

by Wang, Lingzhi, Syn, Nicholas Li-Xun, Subhash, Vinod Vijay, Any, Yijia, Thuya, Win Lwin, Cheow, Esther Sok Hwee, Kong, Li Ren, Yu, Fenggang, Peethala, Praveen C., Wong, Andrea Li-Ann, Laljibhai, Hirpara J., Chinnathambi, Arunachalam, Ong, Pei Shi, Ho, Paul Chi-Lui, Sethi, Gautam, Yong, Wei Peng, Goh, Boon Cher
Published 2020

DUSP16 promotes cancer chemoresistance through regulation of mitochondria-mediated cell death

by Low, Heng Boon, Wong, Zhen Lim, Wu, Bangyuan, Kong, Li Ren, Png, Chin Wen, Cho, Yik-Lam, Li, Chun-Wei, Xiao, Fengchun, Xin, Xuan, Yang, Henry, Loo, Jia Min, Lee, Fiona Yi Xin, Tan, Iain Bee Huat, DasGupta, Ramanuj, Shen, Han-Ming, Schwarz, Herbert, Gascoigne, Nicholas RJ, Goh, Boon Cher, Xu, Xiaohong, Zhang, Yongliang
Published 2021

Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation

by Kong, Li Ren, Ong, Richard Weijie, Tan, Tuan Zea, Salleh, Nur Afiqah Binte Mohamed, Thangavelu, Matan, Chan, Jane Vin, Koh, Lie Yong Judice, Periyasamy, Giridharan, Lau, Jieying Amelia, Le, Thi Bich Uyen, Wang, Lingzhi, Lee, Miyoung, Kannan, Srinivasaraghavan, Verma, Chandra S, Lim, Chwee Ming, Chng, Wee Joo, Lane, David P, Venkitaraman, Ashok, Hung, Huynh The, Cheok, Chit Fang, Goh, Boon Cher
Published 2020

Phase I and biomarker study of OPB-51602, a novel signal transducer and activator of transcription (STAT) 3 inhibitor, in patients with refractory solid malignancies

by Wong, Andrea, Soo, Ross A., Tan, Daniel, Lee, Soo Chin, Lim, Joline S J, Marban, P.C., Kong, Li Ren, Lee, Youngjoo, Wang, Lingzhi, Thuya, Win Lwin, Soong, R., Yee, M.Q., Chin, T.M., Cordero, Maricel Tiemsim, Asuncion, Bernadette Reyna, Pang, B., Pervaiz, Shazib, Hirpara, Jayshree L., Sinha, Arvind, Xu, W.W., Yuasa, M., Tsunoda, T., Motoyama, M., Yamauchi, T., Goh, Boon Cher
Published 2016

A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma

by Kong, Li Ren, Salleh, Nur Afiqah Binte Mohamed, Ong, Richard Weijie, Tan, Tuan Zea, Syn, Nicholas L, Goh, Robby Miguel, Fhu, Chee Wei, Tan, Daniel SW, Iyer, N Gopalakrishna, Kannan, Srinivasaraghavan, Verma, Chandra S, Lim, Yaw Chyn, Soo, Ross, Ho, Jingshan, Huang, Yiqing, Lim, Joline SJ, Yan, Benedict Junrong, Nga, Min En, Lim, Seng Gee, Koeffler, H Phillip, Lee, Soo Chin, Kappei, Dennis, Hung, Huynh The, Goh, Boon Cher
Published 2020

FAM3C in circulating tumor-derived extracellular vesicles promotes non-small cell lung cancer growth in secondary sites

by Thuya, Win Lwin, Kong, Li Ren, Syn, Nicholas L., Ding, Ling-Wen, Cheow, Esther Sok Hwee, Wong, Regina Tong Xin, Wang, Tingting, Goh, Robby Miguel Wen-Jing, Song, Hongyan, Jayasinghe, Migara K., Le, Minh Tn, Hu, Jian Cheng, Yong, Wei-Peng, Lee, Soo-Chin, Wong, Andrea Li-Ann, Sethi, Gautam, Hung, Huynh The, Ho, Paul Chi-Lui, Thiery, Jean-Paul, Sze, Siu Kwan, Guo, Tiannan, Soo, Ross A., Yang, Henry, Lim, Yaw Chyn, Wang, Lingzhi, Goh, Boon-Cher
Published 2023

Integration of antiangiogenic therapy with cisplatin and gemcitabine chemotherapy in patients with nasopharyngeal carcinoma.

by Chong, Wan Qin, Lim, Chwee Ming, Sinha, Arvind Kumar, Tan, Chee Seng, Chan, Gloria Hui Jia, Huang, Yiqing, Barr Kumarakulasinghe, Nesaretnam, Sundar, Raghav, Jeyasekharan, Anand D, Loh, Woei Shyang, Tay, Joshua K., Yadav, Kritika, Wang, Lingzhi, Wong, Andrea L., Kong, Li Ren, Soo, Ross Andrew, Lau, Jieying Amelia, Soon, Yu Yang, Goh, Robby Miguel, Ho, Francis Cho Hao, Chong, Siew Meng, Lee, Soo-Chin, Loh, Kwok Seng, Tai, Bee Choo, Lim, Yaw Chyn, Goh, Boon Cher
Published 2020