Combined inhibition of PD-1/PD-L1, Lag-3, and Tim-3 axes augments antitumor immunity in gastric cancer–T cell coculture models

by Mimura, Kosaku, Kua, Ley-Fang, Xiao, Jin-Fen, Asuncion, Bernadette Reyna, Nakayama, Yuko, Syn, Nicholas, Fazreen, Zul, Soong, Richie, Kono, Koji, Yong, Wei-Peng
Published 2022

High efficacy of BAY 1187982, an FGFR2-ADC, in overcoming drug resistance in a diffuse type gastric cancer patient-derived xenograft model with acquired resistance to pan-FGFR inhi...

by Lau, Wen Min, Teng, Eileen, Huang, Kie Kyon, Tan, Jin Wei, Teh, Ming, Yong, Wei Peng, Sommer, Anette, Schatz, Christoph A, Tan, Patrick, Chan, Shing Leng, So, Jimmy
Published 2019

FBXW5 Promotes Tumorigenesis and Metastasis in Gastric Cancer via Activation of the FAK-Src Signaling Pathway

by Yeo, Subhash, KAZUTO SUDA, HAYRI EMRAH BALCIOGLU, ZHOU SIQIN, THUYA WIN LWIN, LOH XIN YI, Jammula, PRAVEEN CHAKRAVARTHY PEETHALA, Tan, Xie, Wong, Ladoux,Benoit, Ito, YANG HE, Goh, Wang, YONG WEI PENG
Published 2019

Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy

by Limviphuvadh, Vachiranee, Tan, Chee Seng, Konishi, Fumikazu, Jenjaroenpun, Piroon, Xiang, Joy Shengnan, Kremenska, Yuliya, Mu, Yar Soe, Soo, Ross A., Eisenhaber, Frank, Maurer-Stroh, Sebastian, Yong, Wei Peng, Nicholas, Syn, Chin, Lee Soo
Published 2018

Clinical outcome and prognostic factors for Asian patients in Phase I clinical trials

by Loh, Jerold, Wu, Jiaxuan, Chieng, Jenny, Chan, Aurora, Yong, Wei-Peng, Sundar, Raghav, Lee, Soo-Chin, Wong, Andrea, Lim, Joline SJ, Tan, David SP, Soo, Ross, Goh, Boon-Cher, Tai, Bee-Choo, Chee, Cheng E
Published 2023

A randomized phase II trial evaluating the addition of low dose, short course sunitinib to docetaxel in advanced solid tumours

by Ang, Yvonne L. E., Ho, Gwo Fuang, Soo, Ross A., Sundar, Raghav, Tan, Sing Huang, Yong, Wei Peng, Ow, Samuel G. W., Lim, Joline S. J., Chong, Wan Qin, Soe, Phyu Pyar, Tai, Choo, Wang, Lingzhi, Goh, Boon Cher, Lee, Soo-Chin
Published 2020

Phase Ib Dose-Finding Study of Varlitinib Combined with Weekly Paclitaxel With or Without Carboplatin +/- Trastuzumab in Advanced Solid Tumors

by Lee, Matilda Xinwei, Wong, Andrea LA, Ow, Samuel, Sundar, Raghav, Tan, David SP, Soo, Ross A, Chee, Cheng Ean, Lim, Joline SJ, Yong, Wei Peng, Lim, Siew Eng, Goh, Boon Cher, Wang, Lingzhi, Lee, Soo Chin
Published 2022

"3G" Trial: An RNA Editing Signature to Guide Gastric Cancer Chemotherapy

by An, Omer, Song, Yangyang, Ke, Xinyu, So, Jimmy Bok-Yan, Sundar, Raghav, Yang, Henry, Rha, Sun Young, Lee, Ming Hui, Tay, Su Ting, Ong, Xuewen, Tan, Angie Lay Keng, Ng, Matthew Chau Hsien, Tantoso, Erwin, Chen, Leilei, Tan, Patrick, Yong, Wei Peng
Published 2021

Acquired Resistance to FGFR Inhibitor in Diffuse-Type Gastric Cancer through an AKT-Independent PKC-Mediated Phosphorylation of GSK3 beta

by Lau, Wen Min, Teng, Eileen, Huang, Kie Kyon, Tan, Jin Wei, Das, Kakoli, Zang, Zhijiang, Chia, Tania, Teh, Ming, Kono, Koji, Yong, Wei Peng, Shabbir, Asim, Tay, Amy, Phua, Niam Sin, Tan, Patrick, Chan, Shing Leng, So, Jimmy Bok Yan
Published 2021

A novel combinatorial strategy using Seliciclib (R) and Belinostat (R) for eradication of non-small cell lung cancer via apoptosis induction and BID activation

by Ong, Pei-Shi, Wang, Lingzhi, Chia, Deborah Miao-Hui, Seah, Jolyn Yu-Xin, Kong, Li-Ren, Thuya, Win-Lwin, Chinnathambi, Arunachalam, Lau, Jie-Ying Amelia, Wong, Andrea Li-Ann, Yong, Wei-Peng, Yang, Daiwen, Ho, Paul Chi-Lui, Sethi, Gautam, Goh, Boon-Cher
Published 2020

Oncofetal protein IGF2BP1 regulates IQGAP3 expression to maintain stem cell potential in cancer

by Myint, Khine, Chuang, Linda Shyue Huey, Teh, Yu Xuan, Mawan, Nur Astiana, Shi, Edward Jizhong, Mok, Michelle Meng Huang, Nuttonmanit, Napat, Matsuo, Junichi, Li, Ying, Yang, Henry, Okabe, Atsushi, Kaneda, Atsushi, Osato, Motomi, So, Jimmy Bok-Yan, Yong, Wei Peng, Tan, Patrick, Yeoh, Khay Guan, Ito, Yoshiaki
Published 2023

A Phase I, First-in-Human Study of PRL3-zumab in Advanced, Refractory Solid Tumors and Hematological Malignancies

by Chee, Cheng E, Ooi, Melissa, Lee, Soo-Chin, Sundar, Raghav, Heong, Valerie, Yong, Wei-Peng, Ng, Chin Hin, Wong, Andrea, Lim, Joline SJ, Tan, David SP, Soo, Ross, Tan, Joshua TC, Yang, Song, Thura, Min, Al-Aidaroos, Abdul Qader, Chng, Wee Joo, Zeng, Qi, Goh, Boon-Cher
Published 2023

Pan-HDAC inhibition by panobinostat mediates chemosensitization to carboplatin in non-small cell lung cancer via attenuation of EGFR signaling

by Wang, Lingzhi, Syn, Nicholas Li-Xun, Subhash, Vinod Vijay, Any, Yijia, Thuya, Win Lwin, Cheow, Esther Sok Hwee, Kong, Li Ren, Yu, Fenggang, Peethala, Praveen C., Wong, Andrea Li-Ann, Laljibhai, Hirpara J., Chinnathambi, Arunachalam, Ong, Pei Shi, Ho, Paul Chi-Lui, Sethi, Gautam, Yong, Wei Peng, Goh, Boon Cher
Published 2020

Development and validation of a serum microRNA biomarker panel for detecting gastric cancer in a high-risk population

by So, Jimmy Bok Yan, Kapoor, Ritika, Zhu, Feng, Koh, Calvin, Zhou, Lihan, Zou, Ruiyang, Tang, Yew Chung, Goo, Patrick CK, Rha, Sun Young, Chung, Hyun Cheol, Yoong, Joanne, Yap, Celestial T, Rao, Jaideepraj, Chia, Chung-King, Tsao, Stephen, Shabbir, Asim, Lee, Jonathan, Lam, Kong-Peng, Hartman, Mikael, Yong, Wei Peng, Too, Heng-Phon, Yeoh, Khay-Guan
Published 2021

Pan-Asian adapted ESMO Clinical Practice Guidelines for the management of patients with metastatic oesophageal cancer: a JSMO–ESMO initiative endorsed by CSCO, KSMO, MOS, SSO and T...

by Muro, Kei, Lordick, Florian, Tsushima, Takahiro, Pentheroudakis, George, Baba, Eishi, Lu, Zhihao, Cho, Byoung Chul, Nor, I.M., Ng, Matthew, Chen, Li Tzong, Kato, Ken, Li, Jin, Ryu, Min-hee, Wan Zamaniah, Wan Ishak, Yong, Wei Peng, Yeh, Kun Huei, Nakajima, Takako Eguchi, Shitara, Kouhei, Kawakami, Hisato, Narita, Yukiya, Yoshino, Takayuki, Van Cutsem, Eric, Martinelli, Erika, Smyth, Elizabeth C., Arnold, Dirk, Minami, Hironobu, Tabernero, J., Douillard, Jean Yves
Published 2019

Pan-Asian adapted ESMO Clinical Practice Guidelines for the management of patients with metastatic gastric cancer: a JSMO–ESMO initiative endorsed by CSCO, KSMO, MOS, SSO and TOS

by Muro, Kei, Van Cutsem, Eric, Narita, Yukiya, Pentheroudakis, George, Baba, Eishi, Li, Jin, Ryu, Min-hee, Wan Zamaniah, Wan Ishak, Yong, Wei Peng, Yeh, Kun Huei, Kato, Ken, Lu, Zhihao, Cho, Byoung Chul, Nor, I.M., Ng, Matthew, Chen, Li Tzong, Nakajima, Takako Eguchi, Shitara, Kouhei, Kawakami, Hisato, Tsushima, Takahiro, Yoshino, Takayuki, Lordick, Florian, Martinelli, Erika, Smyth, Elizabeth C., Arnold, Dirk, Minami, Hironobu, Tabernero, J., Douillard, Jean Yves
Published 2019

Gelsolin-mediated activation of PI3K/Akt pathway is crucial for hepatocyte growth factor-induced cell scattering in gastric carcinoma

by Huang, Baohua, DENG SHUO, LOO SER YUE, ARPITA DATTA, YAP YAN LIN, Yan, Benedict, OOI CHIA HUEY, DINH THUY DUONG, ZHUO JINGLI, LALCHHANDAMI TOCHHAWNG, SUMA GOPINADHAN, Jegadeesan, Tamilarasi, TAN BOON OOI,PATRICK, SALTO-TELLEZ,MANUEL, YONG WEI PENG, SOONG CHUAN TECK,RICHIE, YEOH KHAY GUAN, GOH YAW CHONG, PETER EDWARD LOBIE, YANG HE, ALAN PREM KUMAR, Maciver, Sutherland K, SO BOK YAN,JIMMY, Yap Suen Mei,Celestial Therese
Published 2020

A phase 1 study of the safety, pharmacokinetics and pharmacodynamics of escalating doses followed by dose expansion of the selective inhibitor of nuclear export (SINE) selinexor in...

by Ho, Jingshan, Heong, Valerie, Yong, Wei Peng, Soo, Ross, Chee, Cheng Ean, Wong, Andrea, Sundar, Raghav, Thian, Yee Liang, Gopinathan, Anil, Pang, Mei Yan, Koe, Priscillia, Jeraj, Santhiay Nathan, Soe, Phyu Pyar, Soe, Mu Yar, Tang, Tiffany, Ng, Matthew CH, Tai, David WM, Tan, Tira JY, Xu, Hongmei, Chang, Hua, Landesman, Yosef, Shah, Jatin, Shacham, Sharon, Lee, Soo Chin, Tan, Daniel SW, Goh, Boon Cher, Tan, David SP
Published 2022

Iqgap3-Ras axis drives stem cell proliferation in the stomach corpus during homoeostasis and repair

by Matsuo, Junichi, Douchi, Daisuke, Myint, Khine, Mon, Naing Naing, Yamamura, Akihiro, Kohu, Kazuyoshi, Heng, Dede Liana, Chen, Sabirah, Mawan, Nur Astiana, Nuttonmanit, Napat, Li, Ying, Srivastava, Supriya, Ho, Shamaine Wei Ting, Lee, Nicole Yee Shin, Lee, Hong Kai, Adachi, Makoto, Tamura, Atsushi, Chen, Jinmiao, Yang, Henry, Ming Teh, So, Jimmy Bok-Yan, Yong, Wei Peng, Tan, Patrick, Yeoh, Khay Guan, Chuang, Linda Shyue Huey, Tsukita, Sachiko, Ito, Yoshiaki
Published 2021

A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets

by Tao, Jiong, Tan, Iain Beehuat, Deng, Niantao, Goh, Liang-Kee, Wang, Hannah, Das, Kakoli, Zhang, Shenli, Lee, Minghui, Wu, Jeanie, Lim, Kiat Hon, Lei, Zhengdeng, Goh, Glenn, Lim, Qing-Yan, Tan, Angie Lay-Keng, Poh, Dianne Yu Sin, Riahi, Sudep, Bell, Sandra, Linnartz, Ronald, Zhu, Feng, Yeoh, Khay Guan, Toh, Han Chong, Yong, Wei Peng, Cheong, Hyun Cheol, Rha, Sun Young, Boussioutas, Alex, Grabsch, Heike, Tan, Patrick, Shi, Michael M., Rozen, Steve G.
Published 2013