Determining signalling nodes for apoptosis by a genetic high-throughput screen

by Lin B., Huntley D., AbuAli G., Langley S.R., Sindelar G., Petretto E., Butcher S., Grimm S.
Published 2018

Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans

by Langley S.R., Bottolo L., Kunes J., Zicha J., Zidek V., Hubner N., Cook S.A., Pravenec M., Aitman T.J., Petretto E.
Published 2018

A bayesian approach for analysis of whole-genome bisulfite sequencing data identifies disease-associated changes in DNA methylation

by Rackham, O.J.L, Langley, S.R, Oates, T, Vradi, E, Harmston, N, Srivastava, P.K, Behmoaras, J, Dellaportas, P, Bottolo, L, Petretto, E
Published 2020

New insights into the genetic control of gene expression using a bayesian multi-tissue approach

by Petretto E., Bottolo L., Langley S.R., Heinig M., McDermott-Roe C., Sarwar R., Pravenec M., Hübner N., Aitman T.J., Cook S.A., Richardson S.
Published 2018

MicroRNA profiles in hippocampal granule cells and plasma of rats with pilocarpine-induced epilepsy - Comparison with human epileptic samples

by Roncon, P, Soukupovà, M, Binaschi, A, Falcicchia, C, Zucchini, S, Ferracin, M, Langley, S.R, Petretto, E, Johnson, M.R, Marucci, G, Michelucci, R, Rubboli, G, Simonato, M
Published 2020

Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice

by Goedeke, L, Salerno, A, Ramírez, C.M, Guo, L, Allen, R.M, Yin, X, Langley, S.R, Esau, C, Wanschel, A, Fisher, E.A, Suárez, Y, Baldán, A, Mayr, M, Fernández-Hernando, C
Published 2020

Rare and common epilepsies converge on a shared gene regulatory network providing opportunities for novel antiepileptic drug discovery

by Delahaye-Duriez A., Srivastava P., Shkura K., Langley S.R., Laaniste L., Moreno-Moral A., Danis B., Mazzuferi M., Foerch P., Gazina E.V., Richards K., Petrou S., Kaminski R.M., Petretto E., Johnson M.R.
Published 2018

Genome-wide analysis of differential RNA editing in epilepsy

by Srivastava, P.K, Bagnati, M, Delahaye-Duriez, A, Ko, J.-H, Rotival, M, Langley, S.R, Shkura, K, Mazzuferi, M, Danis, B, Van Eyll, J, Foerch, P, Behmoaras, J, Kaminski, R.M, Petretto, E, Johnson, M.R
Published 2020

Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects

by Ooi, J., Langley, S.R., Xu, X., Utami, K.H., Sim, B., Huang, Y., Harmston, N.P., Tay, Y.L., Ziaei, A., Zeng, R., Low, D., Aminkeng, F., Sobota, R.M., Ginhoux, F., Petretto, E., Pouladi, M.A.
Published 2021

Genetic Analysis of the Cardiac Methylome at Single Nucleotide Resolution in a Model of Human Cardiovascular Disease

by Johnson M.D., Mueller M., Adamowicz-Brice M., Collins M.J., Gellert P., Maratou K., Srivastava P.K., Rotival M., Butt S., Game L., Atanur S.S., Silver N., Norsworthy P.J., Langley S.R., Petretto E., Pravenec M., Aitman T.J.
Published 2018

Ethnicity-Specific Skeletal Muscle Transcriptional Signatures and Their Relevance to Insulin Resistance in Singapore

by Tan A.L.M., Langley S.R., Tan C.F., Chai J.F., Khoo C.M., Leow M.K.-S., Khoo E.Y.H., Moreno-Moral A., Pravenec M., Rotival M., Sadananthan S.A., Velan S.S., Venkataraman K., Chong Y.S., Lee Y.S., Sim X., Stunkel W., Liu M.H., Tai E.S., Petretto E.
Published 2020

Ethnicity-specific skeletal muscle transcriptional signatures and their relevance to insulin resistance in Singapore

by Tan, Amelia Li Min, Langley, Sarah R., Tan, Chee Fan, Chai, Jin Fang, Khoo, Chin Meng, Leow, Melvin Khee-Shing, Khoo, Eric Yin Hao, Moreno-Moral, Aida, Pravenec, Michal, Rotival, Maxime, Sadananthan, Suresh Anand, Velan, S. Sendhil, Venkataraman, Kavita, Chong, Yap Seng, Lee, Yung Seng, Sim, Xueling, Stunkel, Walter, Liu, Mei Hui, Tai, E. Shyong, Petretto, Enrico
Published 2021

Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques

by Langley, S.R, Willeit, K, Didangelos, A, Matic, L.P, Skroblin, P, Barallobre-Barreiro, J, Lengquist, M, Rungger, G, Kapustin, A, Kedenko, L, Molenaar, C, Lu, R, Barwari, T, Suna, G, Yin, X, Iglseder, B, Paulweber, B, Willeit, P, Shalhoub, J, Pasterkamp, G, Davies, A.H, Monaco, C, Hedin, U, Shanahan, C.M, Willeit, J, Kiechl, S, Mayr, M
Published 2020

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk

by Heinig M., Petretto E., Wallace C., Bottolo L., Rotival M., Lu H., Li Y., Sarwar R., Langley S.R., Bauerfeind A., Hummel O., Lee Y.-A., Paskas S., Rintisch C., Saar K., Cooper J., Buchan R., Gray E.E., Cyster J.G., Jeanette Erdmann, Hengstenberg C., Maouche S., Ouwehand W.H., Rice C.M., Samani N.J., Schunkert H., Goodall A.H., Schulz H., Roider H.G., Vingron M., Blankenberg S., M�nzel T., Zeller T., Szymczak S., Ziegler A., Tiret L., Smyth D.J., Pravenec M., Aitman T.J., Cambien F., Clayton D., Todd J.A., Hubner N., Cook S.A., Braund P., Gracey J., Krishnan U., Moore J.S., Nelson C.P., Pollard H., Attwood T., Crisp-Hihn A., Foad N., Jolley J., Lloyd-Jones H., Muir D., Murray E., O'Leary K., Rankin A., Sambrook J., Godfroy T., Brocheton J., Proust C., Schmitz G., Heimerl S., Lugauer I., Belz S., Gulde S., Linsel-Nitschke P., Sager H., Schroeder L., Lundmark P., Syvannen A.-C., Neudert J., Scholz M., Deloukas P., Gray E., Gwilliams R., Niblett D.
Published 2018