Selinexor, a selective inhibitor of nuclear export, enhances the anti-tumor activity of olaparib in triple negative breast cancer regardless of BRCA1 mutation status

by Marijon, Hélène, Gery, Sigal, Chang, Hua, Landesman, Yosef, Shacham, Sharon, Lee, Dhong Hyun, de Gramont, Aimery, Koeffler, Harold Phillip
Published 2022

Molecular mechanism and therapeutic implications of selinexor (KPT-330) in liposarcoma

by Garg, M, Kanojia, D, Mayakonda, A, Said, J.W, Doan, N.B, Chien, W, Ganesan, T.S, Chuang, L.S.H, Venkatachalam, N, Baloglu, E, Shacham, S, Kauffman, M, Koeffler, H.P
Published 2020

Selinexor (KPT-330) has antitumor activity against anaplastic thyroid carcinoma in vitro and in vivo and enhances sensitivity to doxorubicin

by Garg, M, Kanojia, D, Mayakonda, A, Ganesan, T.S, Sadhanandhan, B, Suresh, S, Sneha, S, Nagare, R.P, Said, J.W, Doan, N.B, Ding, L.-W, Baloglu, E, Shacham, S, Kauffman, M, Koeffler, H.P
Published 2020

Functional genome-wide screening identifies targets and pathways sensitizing pancreatic cancer cells to dasatinib

by Chien W., Sudo M., Ding L.-W., Sun Q.-Y., Wuensche P., Lee K.L., Hattori N., Garg M., Xu L., Zheng Y., Gery S., Wongphayak S., Yang H., Baloglu E., Shacham S., Kauffman M., Mori S., Phillip Koeffler H.
Published 2020

Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor

by Subhash, V.V, Yeo, M.S, Wang, L, Tan, S.H, Wong, F.Y, Thuya, W.L, Tan, W.L, Peethala, P.C, Soe, M.Y, Tan, D.S.P, Padmanabhan, N, Baloglu, E, Shacham, S, Tan, P, Koeffler, H.P, Yong, W.P
Published 2020

Genomic and molecular characterization of esophageal squamous cell carcinoma

by Lin, D.-C., Hao, J.-J., Nagata, Y., Xu, L., Shang, L., Meng, X., Sato, Y., Okuno, Y., Varela, A.M., Ding, L.-W., Garg, M., Liu, L.-Z., Yang, H., Yin, D., Shi, Z.-Z., Jiang, Y.-Y., Gu, W.-Y., Gong, T., Zhang, Y., Xu, X., Kalid, O., Shacham, S., Ogawa, S., Wang, M.-R., Koeffler, H.P.
Published 2014

A phase 1 study of the safety, pharmacokinetics and pharmacodynamics of escalating doses followed by dose expansion of the selective inhibitor of nuclear export (SINE) selinexor in...

by Ho, Jingshan, Heong, Valerie, Yong, Wei Peng, Soo, Ross, Chee, Cheng Ean, Wong, Andrea, Sundar, Raghav, Thian, Yee Liang, Gopinathan, Anil, Pang, Mei Yan, Koe, Priscillia, Jeraj, Santhiay Nathan, Soe, Phyu Pyar, Soe, Mu Yar, Tang, Tiffany, Ng, Matthew CH, Tai, David WM, Tan, Tira JY, Xu, Hongmei, Chang, Hua, Landesman, Yosef, Shah, Jatin, Shacham, Sharon, Lee, Soo Chin, Tan, Daniel SW, Goh, Boon Cher, Tan, David SP
Published 2022