An in silico analysis of the binding affinity of alliin from Allium sativum L. targeting HMGB-1 and IL-6 inflammatory cascade

• Main Authors: Cuabo, Rejie May M., Gabia, Katherine F., Palaypay, Alyssa Bianca F., Roque, Glen Andrei R.
• Format: text
• Language: English
• Published: Animo Repository 2024
• Subjects: Garlic; HMGB proteins; Interleukin-6; Biology
• Online Access: https://animorepository.dlsu.edu.ph/etdb_bio/62
• Institution: De La Salle University

Alcoholic liver disease (ALD) is a spectrum of disease related to excessive intake of alcohol. One of its stages is alcoholic hepatitis (AH) which occurs through severe inflammation of the liver. It has been known that AH is induced by many mechanisms and one of which is endotoxemia. Excessive consu...