Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease

• Main Authors: Schmidt, Vanessa, Baum, Katharina, Lao, Angelyn R., Rateitschak, Katja, Schmitz, Yvonne, Teichmann, Anke, Wiesner, Burkhard, Petersen, Claus Munck, Nykjaer, Anders, Wolf, Jana, Wolkenhauer, Olaf, Willnow, Thomas E.
• Format: text
• Published: Animo Repository 2011
• Subjects: Amyloid beta-protein precursor—Mathematical models; Alzheimer's disease; Mathematics
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/7442
• Institution: De La Salle University

The extent of proteolytic processing of the amyloid precursor protein (APP) into neurotoxic amyloid-β (Aβ) peptides is central to the pathology of Alzheimer's disease (AD). Accordingly, modifiers that increase Aβ production rates are risk factors in the sporadic form of AD. In a novel systems b...