A whole cell pathway screen reveals seven novel chemosensitizers to combat chloroquine resistant malaria

• Main Authors: Ch'ng, Jun-Hong, Mok, Sachel, Bozdech, Zbynek, Lear, Martin James, Boudhar, Aicha, Russell, Bruce, Nosten, Francois, Tan, Kevin Shyong-Wei
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: https://hdl.handle.net/10356/100940; http://hdl.handle.net/10220/16522
• Institution: Nanyang Technological University

Due to the widespread prevalence of resistant parasites, chloroquine (CQ) was removed from front-line antimalarial chemotherapy in the 1990s despite its initial promise of disease eradication. Since then, resistance-conferring mutations have been identified in transporters such as the PfCRT, that...