Molecular dynamics simulations of a new branched antimicrobial peptide : a comparison of force fields

• Main Authors: Li, Jianguo, Lakshminarayanan, Rajamani, Bai, Yang, Liu, Shouping, Zhou, Lei, Pervushin, Konstantin, Verma, Chandra, Beuerman, Roger W.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: Biological Sciences
• Online Access: https://hdl.handle.net/10356/101593; http://hdl.handle.net/10220/18700
• Institution: Nanyang Technological University

Branched antimicrobial peptides are promising as a new class of antibiotics displaying high activity and low toxicity and appear to work through a unique mechanism of action. We explore the structural dynamics of a covalently branched 18 amino acid peptide (referred to as B2088) in aqueous and membr...