Optogenetics reveals a role for accumbal medium spiny neurons expressing dopamine D2 receptors in cocaine-induced behavioral sensitization

• Main Authors: Song, Shelly Sooyun, Kang, Byeong Jun, Wen, Lei, Lee, Hyo Jin, Sim, Hye-ri, Kim, Tae Hyong, Yoon, Sehyoun, Yoon, Bong-June, Augustine, George J., Baik, Ja-Hyun
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences::Human anatomy and physiology::Neurobiology
• Online Access: https://hdl.handle.net/10356/101853; http://hdl.handle.net/10220/24219
• Institution: Nanyang Technological University

Long-lasting, drug-induced adaptations within the nucleus accumbens (NAc) have been proposed to contribute to drug-mediated addictive behaviors. Here we have used an optogenetic approach to examine the role of NAc medium spiny neurons (MSNs) expressing dopamine D2 receptors (D2Rs) in cocaine-induced...