Enantioselective addition of diphenylphosphine to 3-methyl-4-nitro-5-alkenylisoxazoles

• Main Authors: Chew, Renta Jonathan, Huang, Yinhua, Li, Yongxin, Pullarkat, Sumod A., Leung, Pak-Hing
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Chemistry::Organic chemistry
• Online Access: https://hdl.handle.net/10356/102819; http://hdl.handle.net/10220/19200
• Institution: Nanyang Technological University

An enantioselective Michael addition reaction of diphenylphosphine to substituted alkenylisoxazoles has been developed. The reaction proceeds efficiently under mild conditions with high yields (up to 99%) and moderate to excellent enantioselectivities (up to 92%) thus providing a hitherto unavailabl...