A synthesis of 5-hydroxysedamine using hydroformylation

A synthesis of 5-hydroxysedamine, a Sedum alkaloid, has been completed using N,O-heterocycle chemistry to establish the aminoalcohol structure, hydroformylation to form the piperidine ring and diastereoselective dihydroxylation to introduce the 5-hydroxy group.

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Main Authors:	Bates, Roderick Wayland, Nur Filza Mohamed Aslam, Tang, Chi H., Simon, Oliver
Other Authors:	School of Physical and Mathematical Sciences
Format:	Article
Language:	English
Published:	2014
Subjects:	Science::Chemistry::Organic chemistry::Organic synthesis
Online Access:	https://hdl.handle.net/10356/103108 http://hdl.handle.net/10220/24359
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Institution:	Nanyang Technological University
Language:	English

id	sg-ntu-dr.10356-103108
record_format	dspace
spelling	sg-ntu-dr.10356-1031082023-02-28T19:50:18Z A synthesis of 5-hydroxysedamine using hydroformylation Bates, Roderick Wayland Nur Filza Mohamed Aslam Tang, Chi H. Simon, Oliver School of Physical and Mathematical Sciences Science::Chemistry::Organic chemistry::Organic synthesis A synthesis of 5-hydroxysedamine, a Sedum alkaloid, has been completed using N,O-heterocycle chemistry to establish the aminoalcohol structure, hydroformylation to form the piperidine ring and diastereoselective dihydroxylation to introduce the 5-hydroxy group. MOE (Min. of Education, S’pore) Accepted version 2014-12-09T02:04:22Z 2019-12-06T21:05:46Z 2014-12-09T02:04:22Z 2019-12-06T21:05:46Z 2014 2014 Journal Article Bates, R. W., Nur Filza Mohamed Aslam, Tang, C. H., & Simon, O. (2014). A synthesis of 5-hydroxysedamine using hydroformylation. Tetrahedron, 70(12), 2134-2140. 0040-4020 https://hdl.handle.net/10356/103108 http://hdl.handle.net/10220/24359 10.1016/j.tet.2014.02.001 en Tetrahedron Tetrahedron © 2014 Elsevier Ltd. This is the author created version of a work that has been peer reviewed and accepted for publication by Tetrahedron, Elsevier Ltd. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [Article DOI: http://dx.doi.org/10.1016/j.tet.2014.02.001]. 7 p. application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
language	English
topic	Science::Chemistry::Organic chemistry::Organic synthesis
spellingShingle	Science::Chemistry::Organic chemistry::Organic synthesis Bates, Roderick Wayland Nur Filza Mohamed Aslam Tang, Chi H. Simon, Oliver A synthesis of 5-hydroxysedamine using hydroformylation
description	A synthesis of 5-hydroxysedamine, a Sedum alkaloid, has been completed using N,O-heterocycle chemistry to establish the aminoalcohol structure, hydroformylation to form the piperidine ring and diastereoselective dihydroxylation to introduce the 5-hydroxy group.
author2	School of Physical and Mathematical Sciences
author_facet	School of Physical and Mathematical Sciences Bates, Roderick Wayland Nur Filza Mohamed Aslam Tang, Chi H. Simon, Oliver
format	Article
author	Bates, Roderick Wayland Nur Filza Mohamed Aslam Tang, Chi H. Simon, Oliver
author_sort	Bates, Roderick Wayland
title	A synthesis of 5-hydroxysedamine using hydroformylation
title_short	A synthesis of 5-hydroxysedamine using hydroformylation
title_full	A synthesis of 5-hydroxysedamine using hydroformylation
title_fullStr	A synthesis of 5-hydroxysedamine using hydroformylation
title_full_unstemmed	A synthesis of 5-hydroxysedamine using hydroformylation
title_sort	synthesis of 5-hydroxysedamine using hydroformylation
publishDate	2014
url	https://hdl.handle.net/10356/103108 http://hdl.handle.net/10220/24359
_version_	1759853731712598016

A synthesis of 5-hydroxysedamine using hydroformylation

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