A synthesis of 5-hydroxysedamine using hydroformylation

• Main Authors: Bates, Roderick Wayland, Nur Filza Mohamed Aslam, Tang, Chi H., Simon, Oliver
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: Science::Chemistry::Organic chemistry::Organic synthesis
• Online Access: https://hdl.handle.net/10356/103108; http://hdl.handle.net/10220/24359
• Institution: Nanyang Technological University

A synthesis of 5-hydroxysedamine, a Sedum alkaloid, has been completed using N,O-heterocycle chemistry to establish the aminoalcohol structure, hydroformylation to form the piperidine ring and diastereoselective dihydroxylation to introduce the 5-hydroxy group.