Severe acute respiratory syndrome coronavirus envelope protein ion channel activity promotes virus fitness and pathogenesis

• Main Authors: Verdiá-Báguena, Carmina, Castaño-Rodriguez, Carlos, Alcaraz, Antonio, Torres, Jaume, Enjuanes, Luis, Fernandez-Delgado, Raul, Nieto-Torres, Jose L., DeDiego, Marta L., Jimenez-Guardeño, Jose M., Regla-Nava, Jose A., Aguilella, Vicente M.
• Other Authors: Denison, Mark R.
• Format: Article
• Language: English
• Published: 2014
• Subjects: Biological Sciences
• Online Access: https://hdl.handle.net/10356/103424; http://hdl.handle.net/10220/20005
• Institution: Nanyang Technological University

Deletion of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) envelope (E) gene attenuates the virus. E gene encodes a small multifunctional protein that possesses ion channel (IC) activity, an important function in virus-host interaction. To test the contribution of E protein IC activity in...