Inhibition of 3-D tumor spheroids by timed-released hydrophilic and hydrophobic drugs from multilayered polymeric microparticles

• Main Authors: Tan, Ern Yu, Loo, Say Chye Joachim, Lee, Wei Li, Guo, Wei Mei, Ho, Vincent H. B., Saha, Amitaksha, Chong, Han Chung, Tan, Nguan Soon, Widjaja, Effendi
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/103481; http://hdl.handle.net/10220/24526
• Institution: Nanyang Technological University

First-line cancer chemotherapy necessitates high parenteral dosage and repeated dosing of a combination of drugs over a prolonged period. Current commercially available chemotherapeutic agents, such as Doxil and Taxol, are only capable of delivering single drug in a bolus dose. The aim of this study...