SRSF9 selectively represses ADAR2-mediated editing of brain-specific sites in primates

• Main Authors: Zhang, Fan, Srinivasan, Harini, Shanmugam, Raghuvaran, Charles Richard, John Lalith, Zhang, Xiujun, Liu, Kaiwen I., Woo, Cheok Wei A., Chua, Zi Hao M., Buschdorf, Jan Paul, Meaney, Michael J., Tan, Meng How
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2019
• Subjects: RNA; RNA-protein Complexes; DRNTU::Engineering::Chemical engineering::Biochemical engineering
• Online Access: https://hdl.handle.net/10356/103742; http://hdl.handle.net/10220/47392
• Institution: Nanyang Technological University

Adenosine-to-inosine (A-to-I) RNA editing displays diverse spatial patterns across different tissues. However, the human genome encodes only two catalytically active editing enzymes (ADAR1 and ADAR2), suggesting that other regulatory factors help shape the editing landscape. Here, we show that the s...