Direct β-activation of saturated aldehydes to formal michael acceptors through oxidative NHC catalysis

Direct β-activation of saturated aldehydes to formal michael acceptors through oxidative NHC catalysis

Without detours: Oxidative catalysis mediated by N-heterocyclic carbenes (NHCs) enables the direct β-carbon functionalization of saturated aldehydes (see scheme). The reaction proceeds through two sequential oxidative steps to generate ,β-unsaturated triazolium ester equivalents as formal Michael ac...

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Main Authors: Mo, Junming, Shen, Liang, Chi, Robin Yonggui
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2014
Subjects:
DRNTU::Science::Physics
Online Access:https://hdl.handle.net/10356/104151
http://hdl.handle.net/10220/19431
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1041512020-03-07T12:34:57Z Direct β-activation of saturated aldehydes to formal michael acceptors through oxidative NHC catalysis Mo, Junming Shen, Liang Chi, Robin Yonggui School of Physical and Mathematical Sciences DRNTU::Science::Physics Without detours: Oxidative catalysis mediated by N-heterocyclic carbenes (NHCs) enables the direct β-carbon functionalization of saturated aldehydes (see scheme). The reaction proceeds through two sequential oxidative steps to generate ,β-unsaturated triazolium ester equivalents as formal Michael acceptors, which react with 1,3-diketones and β-ketone esters in an enantioselective manner. 2014-05-22T08:42:39Z 2019-12-06T21:27:34Z 2014-05-22T08:42:39Z 2019-12-06T21:27:34Z 2013 2013 Journal Article Mo, J., Shen, L., & Chi, Y. R. (2013). Direct β-Activation of Saturated Aldehydes to Formal Michael Acceptors through Oxidative NHC Catalysis. Angewandte Chemie International Edition, 52(33), 8588–8591. 1433-7851 https://hdl.handle.net/10356/104151 http://hdl.handle.net/10220/19431 10.1002/anie.201302152 173633 en Angewandte chemie international edition © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic DRNTU::Science::Physics
spellingShingle DRNTU::Science::Physics
Mo, Junming
Shen, Liang
Chi, Robin Yonggui
Direct β-activation of saturated aldehydes to formal michael acceptors through oxidative NHC catalysis
description Without detours: Oxidative catalysis mediated by N-heterocyclic carbenes (NHCs) enables the direct β-carbon functionalization of saturated aldehydes (see scheme). The reaction proceeds through two sequential oxidative steps to generate ,β-unsaturated triazolium ester equivalents as formal Michael acceptors, which react with 1,3-diketones and β-ketone esters in an enantioselective manner.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Mo, Junming
Shen, Liang
Chi, Robin Yonggui
format Article
author Mo, Junming
Shen, Liang
Chi, Robin Yonggui
author_sort Mo, Junming
title Direct β-activation of saturated aldehydes to formal michael acceptors through oxidative NHC catalysis
title_short Direct β-activation of saturated aldehydes to formal michael acceptors through oxidative NHC catalysis
title_full Direct β-activation of saturated aldehydes to formal michael acceptors through oxidative NHC catalysis
title_fullStr Direct β-activation of saturated aldehydes to formal michael acceptors through oxidative NHC catalysis
title_full_unstemmed Direct β-activation of saturated aldehydes to formal michael acceptors through oxidative NHC catalysis
title_sort direct β-activation of saturated aldehydes to formal michael acceptors through oxidative nhc catalysis
publishDate 2014
url https://hdl.handle.net/10356/104151
http://hdl.handle.net/10220/19431
_version_ 1681048439858659328

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