Sugar-modified G-quadruplexes : effects of LNA-, 2'F-RNA- and 2'F-ANA-guanosine chemistries on G-quadruplex structure and stability
G-quadruplex-forming oligonucleotides containing modified nucleotide chemistries have demonstrated promising pharmaceutical potential. In this work, we systematically investigate the effects of sugar-modified guanosines on the structure and stability of a (4+0) parallel and a (3+1) hybrid G-quadrupl...
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Main Authors: | Phan, Anh Tuân, Li, Zhe, Lech, Christopher Jacques |
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Other Authors: | School of Physical and Mathematical Sciences |
Format: | Article |
Language: | English |
Published: |
2014
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/104269 http://hdl.handle.net/10220/19559 |
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Institution: | Nanyang Technological University |
Language: | English |
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