Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein

• Main Authors: Lama, Dilraj, Liberatore, Anne-Marie, Frosi, Yuri, Nakhle, Jessica, Tsomaia, Natia, Bashir, Tarig, Lane, David P., Brown, Christopher J., Verma, Chandra Shekhar, Auvin, Serge
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: DRNTU::Science::Biological sciences; Eukaryotic Translation; 4E Protein
• Online Access: https://hdl.handle.net/10356/105502; http://hdl.handle.net/10220/47812
• Institution: Nanyang Technological University

Stapled-peptides have emerged as an exciting class of molecules which can modulate protein–protein interactions. We have used a structure-guided approach to rationally develop a set of hydrocarbon stapled-peptides with high binding affinities and residence times against the oncogenic eukaryotic tran...