Cobalt-catalyzed directed alkylation of olefinic C-H bond with primary and secondary alkyl chlorides
A cobalt–N-heterocyclic carbene catalytic system promotes pyridine-directed olefinic C–H alkylation reactions using a variety of primary and secondary alkyl chlorides under mild conditions. Radical clock experiments suggest that the reaction involves single-electron transfer from the cobalt interme...
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| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2015
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/106742 http://hdl.handle.net/10220/25072 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | A cobalt–N-heterocyclic carbene catalytic system promotes
pyridine-directed olefinic C–H alkylation reactions using a variety of primary and secondary alkyl chlorides under mild conditions. Radical clock experiments suggest that the reaction involves single-electron transfer from the cobalt intermediate to the alkyl chloride. |
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