Cobalt-catalyzed directed alkylation of olefinic C-H bond with primary and secondary alkyl chlorides

• Main Authors: Yamakawa, Takeshi, Yoshikai, Naohiko, Seto, Yuan Wah
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Chemistry::Organic chemistry
• Online Access: https://hdl.handle.net/10356/106742; http://hdl.handle.net/10220/25072
• Institution: Nanyang Technological University

A cobalt–N-heterocyclic carbene catalytic system promotes pyridine-directed olefinic C–H alkylation reactions using a variety of primary and secondary alkyl chlorides under mild conditions. Radical clock experiments suggest that the reaction involves single-electron transfer from the cobalt interme...