Cobalt-catalyzed directed alkylation of olefinic C-H bond with primary and secondary alkyl chlorides

Cobalt-catalyzed directed alkylation of olefinic C-H bond with primary and secondary alkyl chlorides

A cobalt–N-heterocyclic carbene catalytic system promotes pyridine-directed olefinic C–H alkylation reactions using a variety of primary and secondary alkyl chlorides under mild conditions. Radical clock experiments suggest that the reaction involves single-electron transfer from the cobalt interme...

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Main Authors: Yamakawa, Takeshi, Yoshikai, Naohiko, Seto, Yuan Wah
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2015
Subjects:
DRNTU::Science::Chemistry::Organic chemistry
Online Access:https://hdl.handle.net/10356/106742
http://hdl.handle.net/10220/25072
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1067422023-02-28T19:44:51Z Cobalt-catalyzed directed alkylation of olefinic C-H bond with primary and secondary alkyl chlorides Yamakawa, Takeshi Yoshikai, Naohiko Seto, Yuan Wah School of Physical and Mathematical Sciences DRNTU::Science::Chemistry::Organic chemistry A cobalt–N-heterocyclic carbene catalytic system promotes pyridine-directed olefinic C–H alkylation reactions using a variety of primary and secondary alkyl chlorides under mild conditions. Radical clock experiments suggest that the reaction involves single-electron transfer from the cobalt intermediate to the alkyl chloride. Accepted version 2015-02-18T01:53:03Z 2019-12-06T22:17:24Z 2015-02-18T01:53:03Z 2019-12-06T22:17:24Z 2015 2015 Journal Article 5 p. Yamakawa, T., Seto, Y. W., & Yoshikai, N. (2015). Cobalt-catalyzed directed alkylation of olefinic C-H bond with primary and secondary alkyl chlorides. Synlett, 26(03), 340-344. https://hdl.handle.net/10356/106742 http://hdl.handle.net/10220/25072 10.1055/s-0034-1379247 en Synlett © 2015 Georg Thieme Verlag Stuttgart · New York. This is the author created version of a work that has been peer reviewed and accepted for publication by Synlett, Georg Thieme Verlag Stuttgart · New York. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1055/s-0034-1379247]. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Chemistry::Organic chemistry
spellingShingle DRNTU::Science::Chemistry::Organic chemistry
Yamakawa, Takeshi
Yoshikai, Naohiko
Seto, Yuan Wah
Cobalt-catalyzed directed alkylation of olefinic C-H bond with primary and secondary alkyl chlorides
description A cobalt–N-heterocyclic carbene catalytic system promotes pyridine-directed olefinic C–H alkylation reactions using a variety of primary and secondary alkyl chlorides under mild conditions. Radical clock experiments suggest that the reaction involves single-electron transfer from the cobalt intermediate to the alkyl chloride.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Yamakawa, Takeshi
Yoshikai, Naohiko
Seto, Yuan Wah
format Article
author Yamakawa, Takeshi
Yoshikai, Naohiko
Seto, Yuan Wah
author_sort Yamakawa, Takeshi
title Cobalt-catalyzed directed alkylation of olefinic C-H bond with primary and secondary alkyl chlorides
title_short Cobalt-catalyzed directed alkylation of olefinic C-H bond with primary and secondary alkyl chlorides
title_full Cobalt-catalyzed directed alkylation of olefinic C-H bond with primary and secondary alkyl chlorides
title_fullStr Cobalt-catalyzed directed alkylation of olefinic C-H bond with primary and secondary alkyl chlorides
title_full_unstemmed Cobalt-catalyzed directed alkylation of olefinic C-H bond with primary and secondary alkyl chlorides
title_sort cobalt-catalyzed directed alkylation of olefinic c-h bond with primary and secondary alkyl chlorides
publishDate 2015
url https://hdl.handle.net/10356/106742
http://hdl.handle.net/10220/25072
_version_ 1759856627875315712

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