Impaired systemic tetrahydrobiopterin bioavailability and increased oxidized biopterins in pediatric falciparum malaria : association with disease severity

• Main Authors: Granger, Donald L., Rubach, Matthew P., Mukemba, Jackson, Florence, Salvatore, Lopansri, Bert K., Hyland, Keith, Volkheimer, Alicia D., Yeo, Tsin W., Anstey, Nicholas M., Weinberg, J. Brice, Mwaikambo, Esther D.
• Other Authors: Kim, Kami
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/107301; http://hdl.handle.net/10220/25537
• Institution: Nanyang Technological University

Decreased bioavailability of nitric oxide (NO) is a major contributor to the pathophysiology of severe falciparum malaria. Tetrahydrobiopterin (BH4) is an enzyme cofactor required for NO synthesis from L-arginine. We hypothesized that systemic levels of BH4 would be decreased in children with cerebr...