Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes
The unfolded protein response (UPR) is activated by endoplasmic reticulum (ER) stress and is designed to restorecellular homeostasis through multiple intracellular signalling pathways. In mammals, the UPR programmeregulates the expression of hundreds of genes in response to signalling from ATF6, IRE...
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sg-ntu-dr.10356-1366022023-02-28T17:07:38Z Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes Fun, Xiu Hui Thibault, Guillaume School of Biological Sciences Science::Biological sciences Endoplasmic Reticulum Stress Unfolded Protein Response The unfolded protein response (UPR) is activated by endoplasmic reticulum (ER) stress and is designed to restorecellular homeostasis through multiple intracellular signalling pathways. In mammals, the UPR programmeregulates the expression of hundreds of genes in response to signalling from ATF6, IRE1, and PERK. These threehighly conserved stress sensors are activated by the accumulation of unfolded proteins within the ER.Alternatively, IRE1 and PERK sense generalised lipid bilayer stress (LBS) at the ER while ATF6 is activated by anincrease of specific sphingolipids. As a result, the UPR supports cellular robustness as a broad-spectrum com-pensatory pathway that is achieved by deploying a tailored transcriptional programme adapted to the source ofER stress. This review summarises the current understanding of the three ER stress transducers in sensingproteotoxic stress and LBS. The plasticity of the UPR programme in the context of different sources of ER stresswill also be discussed. Accepted version 2020-01-06T08:37:59Z 2020-01-06T08:37:59Z 2019 2020 Journal Article Fun, X. H. & Thibault, G. (2020). Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1865(1), 1-9. doi:10.1016/j.bbalip.2019.04.009 1388-1981 https://hdl.handle.net/10356/136602 10.1016/j.bbalip.2019.04.009 212240 212240 1 1865 1 9 212240 en Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids © 2019 Elsevier. All rights reserved. This paper was published in Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids and is made available with permission of Elsevier. application/pdf |
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Science::Biological sciences Endoplasmic Reticulum Stress Unfolded Protein Response Fun, Xiu Hui Thibault, Guillaume Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes |
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The unfolded protein response (UPR) is activated by endoplasmic reticulum (ER) stress and is designed to restorecellular homeostasis through multiple intracellular signalling pathways. In mammals, the UPR programmeregulates the expression of hundreds of genes in response to signalling from ATF6, IRE1, and PERK. These threehighly conserved stress sensors are activated by the accumulation of unfolded proteins within the ER.Alternatively, IRE1 and PERK sense generalised lipid bilayer stress (LBS) at the ER while ATF6 is activated by anincrease of specific sphingolipids. As a result, the UPR supports cellular robustness as a broad-spectrum com-pensatory pathway that is achieved by deploying a tailored transcriptional programme adapted to the source ofER stress. This review summarises the current understanding of the three ER stress transducers in sensingproteotoxic stress and LBS. The plasticity of the UPR programme in the context of different sources of ER stresswill also be discussed. |
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School of Biological Sciences |
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School of Biological Sciences Fun, Xiu Hui Thibault, Guillaume |
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Article |
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Fun, Xiu Hui Thibault, Guillaume |
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Fun, Xiu Hui |
title |
Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes |
title_short |
Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes |
title_full |
Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes |
title_fullStr |
Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes |
title_full_unstemmed |
Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes |
title_sort |
lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes |
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2020 |
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https://hdl.handle.net/10356/136602 |
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