Guanine anchoring : a strategy for specific targeting of a G-quadruplex using short PNA, LNA and DNA molecules

• المؤلفون الرئيسيون: Tan, Derrick Jing Yang, Das, Poulomi, Winnerdy, Fernaldo Richtia, Lim, Kah Wai, Phan, Anh Tuân
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2020
• الموضوعات: Science::Chemistry; Science::Biological sciences; PNA; DNA
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/142097
• المؤسسة: Nanyang Technological University

Two separate structural elements of a G-quadruplex (G4), a vacant site and a flanking single-strand, provide an opportunity for specific targeting of a particular G4 structure via dual recognition. Here, we show that a short peptide nucleic acid (PNA) can specifically recognize and bind to a G4 at s...