Guanine anchoring : a strategy for specific targeting of a G-quadruplex using short PNA, LNA and DNA molecules

• Main Authors: Tan, Derrick Jing Yang, Das, Poulomi, Winnerdy, Fernaldo Richtia, Lim, Kah Wai, Phan, Anh Tuân
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Chemistry; Science::Biological sciences; PNA; DNA
• Online Access: https://hdl.handle.net/10356/142097
• Institution: Nanyang Technological University

Two separate structural elements of a G-quadruplex (G4), a vacant site and a flanking single-strand, provide an opportunity for specific targeting of a particular G4 structure via dual recognition. Here, we show that a short peptide nucleic acid (PNA) can specifically recognize and bind to a G4 at s...