Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration

• Main Authors: Tan, Chin Hong, Bonham, Luke W., Fan, Chun Chieh, Mormino, Elizabeth C., Sugrue, Leo P., Broce, Iris J., Hess, Christopher P., Yokoyama, Jennifer S., Rabinovici, Gil D., Miller, Bruce L., Yaffe, Kristine., Schellenberg, Gerard D., Kauppi, Karolina, Holland, Dominic, McEvoy, Linda K., Kukull, Walter A., Tosun, Duygu, Weiner, Michael W., Sperling, Reisa A., Bennett, David A., Hyman, Bradley T., Andreassen, Ole A., Dale, Anders M., Desikan, Rahul S.
• 其他作者: School of Social Sciences
• 格式: Article
• 語言: English
• 出版: 2020
• 主題: Social sciences::Psychology; Polygenic Hazard Score; Amyloid
• 在線閱讀: https://hdl.handle.net/10356/142983
• 機構: Nanyang Technological University

Mounting evidence indicates that the polygenic basis of late-onset Alzheimer's disease can be harnessed to identify individuals at greatest risk for cognitive decline. We have previously developed and validated a polygenic hazard score comprising of 31 single nucleotide polymorphisms for predic...