Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration

• Main Authors: Tan, Chin Hong, Bonham, Luke W., Fan, Chun Chieh, Mormino, Elizabeth C., Sugrue, Leo P., Broce, Iris J., Hess, Christopher P., Yokoyama, Jennifer S., Rabinovici, Gil D., Miller, Bruce L., Yaffe, Kristine., Schellenberg, Gerard D., Kauppi, Karolina, Holland, Dominic, McEvoy, Linda K., Kukull, Walter A., Tosun, Duygu, Weiner, Michael W., Sperling, Reisa A., Bennett, David A., Hyman, Bradley T., Andreassen, Ole A., Dale, Anders M., Desikan, Rahul S.
• Other Authors: School of Social Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Social sciences::Psychology; Polygenic Hazard Score; Amyloid
• Online Access: https://hdl.handle.net/10356/142983
• Institution: Nanyang Technological University

Mounting evidence indicates that the polygenic basis of late-onset Alzheimer's disease can be harnessed to identify individuals at greatest risk for cognitive decline. We have previously developed and validated a polygenic hazard score comprising of 31 single nucleotide polymorphisms for predic...