Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration

• المؤلفون الرئيسيون: Tan, Chin Hong, Bonham, Luke W., Fan, Chun Chieh, Mormino, Elizabeth C., Sugrue, Leo P., Broce, Iris J., Hess, Christopher P., Yokoyama, Jennifer S., Rabinovici, Gil D., Miller, Bruce L., Yaffe, Kristine., Schellenberg, Gerard D., Kauppi, Karolina, Holland, Dominic, McEvoy, Linda K., Kukull, Walter A., Tosun, Duygu, Weiner, Michael W., Sperling, Reisa A., Bennett, David A., Hyman, Bradley T., Andreassen, Ole A., Dale, Anders M., Desikan, Rahul S.
• مؤلفون آخرون: School of Social Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2020
• الموضوعات: Social sciences::Psychology; Polygenic Hazard Score; Amyloid
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/142983
• المؤسسة: Nanyang Technological University

Mounting evidence indicates that the polygenic basis of late-onset Alzheimer's disease can be harnessed to identify individuals at greatest risk for cognitive decline. We have previously developed and validated a polygenic hazard score comprising of 31 single nucleotide polymorphisms for predic...