Analysis of interactions between telomeric i-motif DNA and a cyclic tetraoxazole compound

Analysis of interactions between telomeric i-motif DNA and a cyclic tetraoxazole compound

The interaction of a macrocyclic tetraoxazole compound, L2H2-4OTD (1), with two aminoalkyl side chains and telomeric i-motif, was investigated by means of electrophoretic mobility shift assay, circular dichroism spectroscopy, mass spectrometry and NMR spectroscopy analyses. The results indicate that...

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Bibliographic Details
Main Authors: Shadi Sedghi Masoud, Yamaoki, Yudai, Ma, Yue, Marchand, Adrien, Winnerdy, Fernaldo Richtia, Gabelica, Valérie, Phan, Anh Tuân, Katahira, Masato, Nagasawa, Kazuo
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2020
Subjects:
Engineering::Chemical engineering::Biotechnology
DNA
G-quadruplexes
Online Access:https://hdl.handle.net/10356/144011
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Institution: Nanyang Technological University
Language: English
Description
Summary:The interaction of a macrocyclic tetraoxazole compound, L2H2-4OTD (1), with two aminoalkyl side chains and telomeric i-motif, was investigated by means of electrophoretic mobility shift assay, circular dichroism spectroscopy, mass spectrometry and NMR spectroscopy analyses. The results indicate that 1 interacts with the i-motif structure at two preferred binding sites.

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