Analysis of interactions between telomeric i-motif DNA and a cyclic tetraoxazole compound

• Main Authors: Shadi Sedghi Masoud, Yamaoki, Yudai, Ma, Yue, Marchand, Adrien, Winnerdy, Fernaldo Richtia, Gabelica, Valérie, Phan, Anh Tuân, Katahira, Masato, Nagasawa, Kazuo
• 其他作者: School of Physical and Mathematical Sciences
• 格式: Article
• 語言: English
• 出版: 2020
• 主題: Engineering::Chemical engineering::Biotechnology; DNA; G-quadruplexes
• 在線閱讀: https://hdl.handle.net/10356/144011
• 機構: Nanyang Technological University

The interaction of a macrocyclic tetraoxazole compound, L2H2-4OTD (1), with two aminoalkyl side chains and telomeric i-motif, was investigated by means of electrophoretic mobility shift assay, circular dichroism spectroscopy, mass spectrometry and NMR spectroscopy analyses. The results indicate that...