Analysis of interactions between telomeric i-motif DNA and a cyclic tetraoxazole compound

• Main Authors: Shadi Sedghi Masoud, Yamaoki, Yudai, Ma, Yue, Marchand, Adrien, Winnerdy, Fernaldo Richtia, Gabelica, Valérie, Phan, Anh Tuân, Katahira, Masato, Nagasawa, Kazuo
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Engineering::Chemical engineering::Biotechnology; DNA; G-quadruplexes
• Online Access: https://hdl.handle.net/10356/144011
• Institution: Nanyang Technological University

The interaction of a macrocyclic tetraoxazole compound, L2H2-4OTD (1), with two aminoalkyl side chains and telomeric i-motif, was investigated by means of electrophoretic mobility shift assay, circular dichroism spectroscopy, mass spectrometry and NMR spectroscopy analyses. The results indicate that 1 interacts with the i-motif structure at two preferred binding sites.