Small molecules targeting the inactive form of the Mnk1/2 kinases

Small molecules targeting the inactive form of the Mnk1/2 kinases

Overexpression of the eukaryotic initiation factor 4E (eIF4E) is linked to a variety of cancers. Both mitogen-activated protein kinases-interacting kinases 1 and 2 (Mnk1/2) activate the oncogene eIF4E through posttranslational modification (phosphorylating it at the conserved Ser209). Inhibition of...

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Bibliographic Details
Main Authors: Kannan, Srinivasaraghavan, Pradhan, Mohan R., Cherian, Joseph, Joseph, Thomas L., Poh, Zhi Ying, Hai Yan, Yang, Melvyn, Ho, Boping, Liu, Jeffrey, Hill, Nacro, Kassoum, Verma, Chandra Shekhar
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2021
Subjects:
Science::Biological sciences
Peptides and Proteins
Molecules
Online Access:https://hdl.handle.net/10356/146896
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Institution: Nanyang Technological University
Language: English

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https://hdl.handle.net/10356/146896

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